A 3D-printed biomimetic tumour angiogenesis model
A 3D-printed biomimetic tumour angiogenesis model
A German university offers a model that can be used to analyse tumour growth, tumour angiogenesis and therapeutic effects on a 3D-printed cell model. No animal tissue is needed. Therefore, this 3D-printed tumour model represents an ideal in-vitro-prescreening system for testing pharmaceuticals and diagnostics and might be able to circumvent or at least reduce the number of animal tests in drug development. Licensees are sought.
Despite major progress in finding alternative methods to animal use in drug discovery and development, laboratory animal testing is in many instances still inevitable. The law also requires animal testing to determine the safety and efficacy of new medicines before testing in humans. To reduce the number of experimental animals, several in-vitro-screening systems have been developed using different 3D-in-vitro-tissue-engineering approaches. However, even though significant progress has been made, there is to date still no satisfying in-vitro-screening system available, which might represent a suitable alternative to animal studies. A German university is working on a new solution: Here 3D-printed structures are produced to generate a 3D-biomimetic tumour-angio¬genesis model. In a first step, a supply channel covered by an endothelial cell layer is generated using the 3D-bioprinting process and in a second step, tumour cells are embedded into a surrounding hydrogel-matrix cell-suspension. Then, angiogenesis will start from the supply channel towards the tumour cells (which release angiogenic factors) leading to a vascularized and perfusable tumour. This model can be used to analyse tumour growth, tumour angiogenesis and therapeutic effects on the 3D-printed cell model. This 3D-tumour model can be designed from pure biologic material (hydrogels and cells) without the need of synthetic development processes. No animal tissue is needed. Therefore, this 3D-printed Tumour Model represents an ideal in-vitro-prescreening system for testing pharmaceuticals and diagnostics and might be able to circumvent or at least reduce the number of animal tests in drug development. Licensees from pharmaceutical and biotechnology industry are sought to use the invention commercially.
Type: Technology Offer
Country: Germany
Profile updated on: 19/04/2022
Profile valid until: 19/10/2022
Partnership
| Development stage | Under development/lab tested |
|---|---|
| Development stage - comment | The technology has been validated in relevant environment. Technology readiness level (TRL): 5 |
| Cooperation Ipr Status | Patent(s) applied for but not yet granted |
| Cooperation Ipr Comment | Patent applied in Europe and US. |
| Cooperation Partner Area | The university is offering access for commercial use in terms of a license agreement. Potential licensees are biotechnology industry and pharmaceutical industry interested in the new strategies in the 3D-cell-printing of tumour models and alternatives to animal testing. |
| Cooperation Partner Sought |
Company / Organisation
| Organisation type | University |
|---|---|
| Company Turnover | |
| Company Since | 0 |
| Company Transnational | Si |
Technological fields
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3D printing
ELECTRONICS; IT AND TELECOMMS / Electronic circuits; components and equipment
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Medical Research
BIOLOGICAL SCIENCES / Medicine; Human Health
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Analyses / Test Facilities and Methods
MEASUREMENTS AND STANDARDS / Measurement Tools
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Pharmaceutics
OTHER INDUSTRIAL TECHNOLOGIES / Chemical Technology and Engineering
Attachments
| # | File Preview | File name |
|---|---|---|
| 1 | 3d Model.jpg | |
| 2 | 3d Model.jpg | |
| 3 | 3d Model.jpg | |
| 4 | 3d Model.jpg | |
| 5 | 3d Model.jpg |